Sam is a washed-out baseball player named Lester 'Doc' Fuller (played by Owen Rutledge) who has to help a younger and angrier player get into the major leagues, the player reminding him of Al when they first met.

Sam leaps into a man named Clyde (played by Glenn Edden) just as he is about to join the KKK, out of respect for the racist family he has married into. He must prevent Black civil rights leader Nathaniel from being lynched by the Klan, as well as trying to explain to his host's son the evils of racism. Due to Sam's upbringing, he finds it very difficult to act like the person he has leaped into to avoid his own lynching.

Sam is Frank Bianca (played by Robert Jacobs), a male hair stylist living with his girlfriend, a single mother. When her child witnesses a murder of a mall drugstore clerk just as Sam leaps in, the boy's mother won't let him tell the police what he saw, and the killer is getting closer and closer to make sure that he never will.

Sam leaps into Katie McBain (played by Cheryl Pollak), a woman who has just been raped by the town's All-American boy. He must make sure that justice is done, resulting in the woman herself being brought into the Imaging Chamber to testify at the rapist's trial.

In a very bizarre out-of-the-human host, Sam leaps into Bobo, an astro-chimp whom he must get into the space program – or he'll disappear forever due to unethical helmet testing methods.

Sam leaps into a man named Joseph 'Joe' Thurlow (played by Will Schaub) who's dating a much, much older woman and must convince her not to move back to Cleveland with her straight-arrow son and his wife. And somehow he also has to get through a nude version of Hamlet.

As a rash of serial murders take place in San Francisco, Sam leaps into a television reporter named Dylan Powell (played by Harker Wade) who must prevent a psychic who is helping the police from becoming the next victim. But when she discovers who Sam really is, they fall for each other and the ordeal becomes very personal.

Sam leaps into Cheree (played by Tiffany Jameson), a member of an all-girl teenage R&B trio, and must prevent one of the singers from signing a cheap contract and ruining their lives.

Sam is a New York City taxicab driver named Max Greenman (played by Ross Partridge) who's trying to earn enough money to get his father his own medallion. Along the way, he meets a woman (played by Liz Torres) who claims to be an angel and can see Al, pretending to believe him to be the devil.

Sam leaps into a man named Davey Parker (played by Rafe Battiste) who's part of a trio comedy act, with his male and female partner so in love with each other that they cannot face it. Sam must get the couple to see that they love each other, and prevent one of the comedians from being killed by the Mafia.

Sam leaps into a younger Al 'Bingo' Calavicci (played by Jamie Walters) who is on trial for the murder and rape of his commander's wife. But when Sam's actions unintentionally prevent the witness whose testimony cleared Al in the real history from testifying before she dies, Sam discovers that Project Quantum Leap now exists in an alternate future in which Al was executed in the gas chamber.